A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin

Toxicon. 2014 Dec 15;92:36-41. doi: 10.1016/j.toxicon.2014.09.006. Epub 2014 Sep 28.

Abstract

Due to the fast-acting nature of ricin, staphylococcal enterotoxin B (SEB), and Clostridium perfringens epsilon toxin (ETX), it is necessary that therapeutic interventions following a bioterrorism incident by one of these toxins occur as soon as possible after intoxication. Moreover, because the clinical manifestations of intoxication by these agents are likely to be indistinguishable from each other, especially following aerosol exposure, we have developed a cocktail of chimeric monoclonal antibodies that is capable of neutralizing all three toxins. The efficacy of this cocktail was demonstrated in mouse models of lethal dose toxin challenge.

Keywords: Antibody; Biodefense; Therapeutic; Toxin.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antibodies, Monoclonal / pharmacology*
  • Bacterial Toxins / toxicity*
  • Bioterrorism / prevention & control*
  • Enterotoxins / toxicity*
  • Female
  • Mice
  • Mice, Inbred BALB C
  • Neutralization Tests
  • Poisoning / prevention & control*
  • Recombinant Fusion Proteins / pharmacology*
  • Ricin / toxicity*

Substances

  • Antibodies, Monoclonal
  • Bacterial Toxins
  • Clostridium perfringens epsilon-toxin
  • Enterotoxins
  • Recombinant Fusion Proteins
  • enterotoxin B, staphylococcal
  • Ricin