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, 44 (2), 375-8

Characterization of ATP Alternations in an Alzheimer's Disease Transgenic Mouse Model

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Characterization of ATP Alternations in an Alzheimer's Disease Transgenic Mouse Model

Cheng Zhang et al. J Alzheimers Dis.

Abstract

Mitochondrial impairment as evidenced by decline in adenosine 5'-triphosphate (ATP) is associated with oxidative stress in Alzheimer's disease neuropathology and suggests that mitochondria may fail to maintain cellular energy, through reduced ATP production in neurons. To gain insights into the ATP characteristics of Alzheimer's disease transgenic (Tg) mice, we investigated ATP contents in the brain and whole blood of Tg mice at three ages (1-, 5-, and 24-months old). Overall, our results demonstrate that tissue ATP contents in Tg mice are significantly reduced, suggesting a decrease of tissue ATP production and mitochondrial dysfunction.

Keywords: Adenosine 5′-triphosphate (ATP) contents; Alzheimer's disease; Alzheimer's disease transgenic mouse model; oxidative stress.

Figures

Figure 1
Figure 1
ATP contents were detected by ATP bioluminescence assay in the brain and whole blood of Wt and Tg mice at 3 age stages (1-, 5- and 24-month-old). (A) ATP levels in brains of Wt and Tg mice at different age stages. (B) ATP levels in whole blood samples of Wt and Tg animals at 3 ages. All data are expressed as Mean ± SEM, N=3/group. Statistical analyses were conducted via 2-way ANOVA with Tukey’s Multiple Comparison post-hoc test. Age: 1- v.s. 24-month. +P<0.05. Genotype: Wt v.s. Tg. *P<0.05, **P<0.01.

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