Women with endometriosis at first pregnancy have an increased risk of adverse obstetric outcome

J Matern Fetal Neonatal Med. 2015;28(15):1795-8. doi: 10.3109/14767058.2014.968843. Epub 2014 Oct 9.

Abstract

Objective: To evaluate pregnancy, delivery and neonatal outcome in singleton primiparous versus multiparous women with/without endometriosis.

Methods: Multicentric, observational and cohort study on a group of Caucasian pregnant women (n = 2239) interviewed during their hospitalization for delivery in five Italian Gynecologic and Obstetric Units (Siena, Rome, Padua, Varese and Florence).

Results: Primiparous women with endometriosis (n = 219) showed significantly higher risk of small for gestational age fetuses (OR: 2.72, 95% CI 1.46-5.06), gestational diabetes (OR: 2.13, 95% CI 1.32-3.44), preterm premature rupture of membranes (OR: 2.93, 95% CI 1.24-6.87) and preterm birth (OR: 2.24, 95% CI 1.46-3.44), and were hospitalized for a longer period of time (p < 0.0001) comparing with control group (n = 1331). Multiparous women with endometriosis (n = 97) delivered significantly more often small for gestational age fetuses (OR: 2.93, 95% CI 1.28-6.67) than control group (n = 592). Newborns of primiparous women with endometriosis needed more frequently intensive care (p = 0.05) and were hospitalized for a longer period of time (p < 0.0001).

Conclusions: Women with endometriosis at first pregnancy have an increased risk of impaired obstetric outcome, while a reduced number of complications occur in the successive gestation. Therefore, it is worthy for obstetricians to increase the surveillance in nulliparous women with endometriosis during pregnancy.

Keywords: Endometriosis; gestational diabetes; neonatal complications; pPROM; pregnancy outcome; preterm birth; small for gestational age.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Endometriosis / epidemiology*
  • Female
  • Gestational Age
  • Humans
  • Incidence
  • Infant, Newborn
  • Male
  • Multicenter Studies as Topic
  • Parity
  • Pregnancy
  • Pregnancy Complications / epidemiology*
  • Pregnancy Outcome / epidemiology*
  • Premature Birth / epidemiology
  • Risk Factors
  • Uterine Diseases / epidemiology*