Translational research on Barrett's esophagus

Ann N Y Acad Sci. 2014 Sep;1325:170-86. doi: 10.1111/nyas.12531.

Abstract

The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on translational research on Barrett's esophagus that address evidence for genetic instability in esophageal cancer; the role of microsatellite instability; the use of histologic and serum Doublecortin-like kinase 1 expression for progression of Barrett's esophagus to adenocarcinoma; the oxidative stress in Barrett's tumorigenesis; the genomic alterations in esophageal cancer; in vivo modeling in Barrett's esophagus; epigenetic and transcriptional regulation in Barrett's esophagus and esophageal adenocarcinoma; and normal and disordered regeneration in Barrett's esophagus.

Keywords: Barrett's esophagus; DCLK; OESO; esophageal adenocarcinoma; microsatellite instability; modeling; oxidative stress.

Publication types

  • Congress

MeSH terms

  • Animals
  • Barrett Esophagus / diagnosis*
  • Barrett Esophagus / genetics*
  • Barrett Esophagus / therapy
  • Biomarkers, Tumor / genetics
  • Disease Progression*
  • Humans
  • Microsatellite Repeats / genetics
  • Oxidative Stress / genetics
  • Paris
  • Translational Medical Research / methods*
  • Translational Medical Research / trends

Substances

  • Biomarkers, Tumor