Elevated concentrations of circulating cytokines and correlations with nerve conduction velocity in human peripheral nerves

J Neuroimmunol. 2014 Dec 15;277(1-2):134-9. doi: 10.1016/j.jneuroim.2014.09.010. Epub 2014 Sep 19.

Abstract

The purpose of the current study was to quantify the potential relationship between various cytokines and peripheral nerve function in humans, in-vivo. Measures of nerve conduction velocity (NCV) were examined prior to and following the induction of a cytokine spike. A significant negative correlation was found between the change in IL-1ra and the change in NCV at 24h post-exercise (r=-0.65, p=0.02) while a significant positive correlation was found between the change in IL-6 and the change in NCV at 2h post-exercise (r=0.61, p=0.048). It may be possible that different cytokines induce a unique neural influence at elevated concentrations.

Keywords: Channelopathy; Interleukin-10; Interleukin-1ra; Interleukin-6; Nerve conduction velocity; Tumor necrosis factor-alpha.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Antirheumatic Agents / pharmacology
  • Cytokines / blood*
  • Electric Stimulation
  • Exercise
  • Female
  • Humans
  • Interleukin 1 Receptor Antagonist Protein / pharmacology
  • Male
  • Neural Conduction / drug effects
  • Neural Conduction / physiology*
  • Peripheral Nerves / drug effects
  • Peripheral Nerves / physiology*
  • Statistics as Topic
  • Time Factors
  • Young Adult

Substances

  • Antirheumatic Agents
  • Cytokines
  • Interleukin 1 Receptor Antagonist Protein