Splicing together sister chromatids

EMBO J. 2014 Nov 18;33(22):2601-3. doi: 10.15252/embj.201489988. Epub 2014 Sep 29.

Abstract

Splicing of pre‐mRNAs is a necessary step for expression of the majority of genes in higher eukaryotes, and its regulation through alternative splice site selection shapes their proteomes. Defects in multiple splicing factors result in aberrant mitotic progression, although the molecular basis for this observation has remained elusive. Recent papers in The EMBO Journal and EMBO Reports reveal that expression of sororin, a critical regulator that stabilizes cohesin rings in sister chromatids, is exquisitely sensitive to defects in the splicing machinery, thus explaining the striking link between spliceosome function and chromosome segregation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Cell Cycle Proteins / metabolism*
  • Chromatids / metabolism*
  • Cytoskeletal Proteins / metabolism*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell*
  • Mutation*
  • Neoplasm Proteins*
  • Nuclear Receptor Coactivators / metabolism*
  • Phosphoproteins*
  • RNA Precursors / metabolism*
  • RNA Splicing / physiology*
  • RNA Splicing Factors
  • RNA, Neoplasm*
  • Ribonucleoprotein, U2 Small Nuclear*
  • Sister Chromatid Exchange*

Substances

  • APC2 protein, human
  • Adaptor Proteins, Signal Transducing
  • CDCA5 protein, human
  • Cell Cycle Proteins
  • Cytoskeletal Proteins
  • Neoplasm Proteins
  • Nuclear Receptor Coactivators
  • Phosphoproteins
  • RNA Precursors
  • RNA Splicing Factors
  • RNA, Neoplasm
  • Ribonucleoprotein, U2 Small Nuclear
  • SF3B1 protein, human
  • SNW1 protein, human