Organic nanoparticles with aggregation-induced emission for tracking bone marrow stromal cells in the rat ischemic stroke model

Chem Commun (Camb). 2014 Dec 14;50(96):15136-9. doi: 10.1039/c4cc06921h.

Abstract

Organic nanoparticles (NPs) with aggregation-induced emission (AIE) have been successfully used for tracking bone marrow stromal cells (BMSCs) in rats with ischemic stroke, highlighting the great potential of such fluorescent NPs in understanding the fate of transplanted stem cells for cell-based therapies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Marrow Cells / cytology
  • Brain / pathology
  • Cell Tracking*
  • Cells, Cultured
  • Disease Models, Animal
  • Fluorescent Dyes / chemistry
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / metabolism*
  • Microscopy, Fluorescence
  • Nanoparticles / chemistry
  • Nanoparticles / metabolism*
  • Organic Chemicals / chemistry*
  • Pyrans / chemistry
  • Rats
  • Stroke / metabolism
  • Stroke / pathology
  • Stroke / therapy

Substances

  • Fluorescent Dyes
  • Organic Chemicals
  • Pyrans