Worming toward transdifferentiation, one (Epigenetic) step at a time

Dev Cell. 2014 Sep 29;30(6):641-2. doi: 10.1016/j.devcel.2014.09.003.


Manipulation of cellular identity in the laboratory is generally inefficient due to stochastic events, including epigenomic alterations. Recently in Science, Zuryn et al. (2014) demonstrate that the efficiency of a naturally occurring transdifferentiation event in Caenorhabditis elegans is ensured through stepwise epigenetic modifications during specific phases of lineage conversion.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / cytology*
  • Caenorhabditis elegans Proteins / metabolism*
  • Cell Transdifferentiation*
  • Histone Demethylases / metabolism*
  • Histone-Lysine N-Methyltransferase / metabolism*
  • Histones / metabolism*
  • Motor Neurons / cytology*


  • Caenorhabditis elegans Proteins
  • Histones
  • Histone Demethylases
  • Histone-Lysine N-Methyltransferase