Association between prenatal exposure to metals and neonatal morbidity

J Toxicol Environ Health A. 2014;77(21):1281-4. doi: 10.1080/15287394.2014.932313.

Abstract

An association between prenatal exposure to (semi-)metals and of neonatal morbidity was assessed by introducing an oxidative stress as a possible intermediate step. An oxidative stress was measured by cell proliferation (CP) ratio in umbilical cord blood cells. Urine samples of 18 out of 58 enrolled women (31%) were positive for (semi-)metals; 25.9% of women were positive for aluminum (Al). The CP ratio was higher (1) in subjects with Al, (2) in mothers to newborns diagnosed as small-for-gestational age (p value = .052), (3) neonates that weighed less (p value = .079), and (4) in women who experienced repeated abortions (p value = .049). Our findings suggest the possibility of metal-induced oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cell Proliferation / drug effects
  • Female
  • Fetal Blood / cytology
  • Fetal Blood / drug effects
  • Fetal Blood / metabolism
  • Gestational Age
  • Humans
  • Limit of Detection
  • Maternal Exposure / adverse effects*
  • Metals / administration & dosage
  • Metals / toxicity*
  • Metals / urine
  • Oxidative Stress / drug effects
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Surveys and Questionnaires
  • Young Adult

Substances

  • Metals