[Drug-related anaphylactic shocks: under-reporting and PMSI]

Therapie. Nov-Dec 2014;69(6):483-90. doi: 10.2515/therapie/2014057. Epub 2014 Oct 1.
[Article in French]


Aim: To evaluate the value of research in the case-mix database to identify cases of drug-related anaphylactic or anaphylactoid shock.

Methods: Hospital stays of patients discharged from the University Hospital of Saint-Étienne between July 1st 2009 and June 30th 2012. Five codes from the international classification of diseases were selected: T88.6, T88.2, J39.3, T80.5 and T78.2.

Results: Among 89 cases identified by the programme for medicalization of information system (programme de médicalisation des systèmes d'information, PMSI), 40 were selected (45%). Of these, 16 cases were spontaneously reported by physicians. The unspecific code "anaphylactic shock unspecified (T78.2)" was coded for 57.5% of cases.

Conclusion: The study confirms the interest of the PMSI as a tool for health monitoring, in addition to spontaneous reporting. Nevertheless, coding with insufficient precision about the causal role of the drug, requires a return to the medical record and so an important time consuming process.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Adverse Drug Reaction Reporting Systems / standards*
  • Aged
  • Anaphylaxis / chemically induced
  • Anaphylaxis / epidemiology*
  • Anaphylaxis / therapy
  • Child
  • Databases, Factual
  • Drug Hypersensitivity / complications
  • Drug Hypersensitivity / epidemiology*
  • Drug Hypersensitivity / therapy
  • Female
  • Humans
  • Male
  • Medical Records Systems, Computerized / standards
  • Middle Aged
  • Retrospective Studies
  • Young Adult