Pharmacological Evaluation of Antihypertensive Effect of Aerial Parts of Thymus Linearis Benth

Acta Pol Pharm. Jul-Aug 2014;71(4):677-82.

Abstract

Traditionally Thymus linearis Benth. have been used for treatment of various diseases including hypertension. The present study was conducted to evaluate the hypotensive and antihypertensive effect of aqueous methanolic extract of aerial parts of Thymus linearis Benth. in normotensive and hypertensive rats. Acute and subchronic studies were also conducted. The aqueous methanolic extract produced a significant decrease in SBP, DBP, MBP and heart rate of both normotensive and hypertensive rats. LDv, of the extract was found to be 3000 mg/kg. The extract also exhibited a reduction in serum ALT, AST, ALP, cholesterol, triglycerides and LDL levels, while a significant increase in HDL level was observed. It is conceivable therefore, that Thymus linearis Benth. contains certain active compound(s) that are possibly responsible for the observed antihypertensive activity. Moreover, these findings further authenticate the traditional use of this plant in folklore medicine.

MeSH terms

  • Animals
  • Antihypertensive Agents / pharmacology*
  • Blood Pressure / drug effects
  • Female
  • Heart Rate / drug effects
  • Male
  • Plant Components, Aerial
  • Plant Extracts / pharmacology*
  • Plant Extracts / toxicity
  • Rats
  • Rats, Sprague-Dawley
  • Thymus Plant*

Substances

  • Antihypertensive Agents
  • Plant Extracts