ViRBase: a resource for virus-host ncRNA-associated interactions

Nucleic Acids Res. 2015 Jan;43(Database issue):D578-82. doi: 10.1093/nar/gku903. Epub 2014 Oct 1.


Increasing evidence reveals that diverse non-coding RNAs (ncRNAs) play critically important roles in viral infection. Viruses can use diverse ncRNAs to manipulate both cellular and viral gene expression to establish a host environment conducive to the completion of the viral life cycle. Many host cellular ncRNAs can also directly or indirectly influence viral replication and even target virus genomes. ViRBase ( aims to provide the scientific community with a resource for efficient browsing and visualization of virus-host ncRNA-associated interactions and interaction networks in viral infection. The current version of ViRBase documents more than 12,000 viral and cellular ncRNA-associated virus-virus, virus-host, host-virus and host-host interactions involving more than 460 non-redundant ncRNAs and 4400 protein-coding genes from between more than 60 viruses and 20 hosts. Users can query, browse and manipulate these virus-host ncRNA-associated interactions. ViRBase will be of help in uncovering the generic organizing principles of cellular virus-host ncRNA-associated interaction networks in viral infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Databases, Genetic*
  • Internet
  • Proteins / metabolism
  • RNA, Untranslated / metabolism*
  • Virus Diseases / genetics*
  • Virus Diseases / metabolism
  • Virus Diseases / virology*
  • Viruses / metabolism


  • Proteins
  • RNA, Untranslated