Short-term outcome of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: preliminary analysis of a multicentre study

Anticancer Res. 2014 Oct;34(10):5689-93.


Aim: To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy.

Patients and methods: A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis.

Results: In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity.

Conclusion: Careful patient selection has to be performed to improve clinical outcomes.

Keywords: Cytoreductive surgery; HIPEC; hyperthermia; morbidity; mortality.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Cause of Death
  • Chemotherapy, Cancer, Regional Perfusion
  • Combined Modality Therapy
  • Comorbidity
  • Female
  • Humans
  • Hyperthermia, Induced*
  • Male
  • Middle Aged
  • Palliative Care*
  • Peritoneal Neoplasms / diagnosis
  • Peritoneal Neoplasms / drug therapy*
  • Peritoneal Neoplasms / mortality
  • Peritoneal Neoplasms / surgery*
  • Retrospective Studies
  • Treatment Outcome