Shape-controlled synthesis of gold nanostructures using DNA origami molds

Nano Lett. 2014 Nov 12;14(11):6693-8. doi: 10.1021/nl503441v. Epub 2014 Oct 2.


We introduce a new concept that allows the synthesis of inorganic nanoparticles with programmable shape. Three-dimensional DNA origami nanostructures harboring an internal cavity are used as molds. A small gold nanoparticle within the cavity nucleates solution-based gold deposition leading to mold filling. We demonstrate the fabrication of 40 nm long rodlike gold particles with quadratic cross section and the formation of higher order assemblies of the obtained particles, which is mediated by their DNA shell.

Keywords: DNA metallization; DNA nanostructures; Metal nanoparticles; plasmonics; seeded growth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry*
  • Gold / chemistry*
  • Metal Nanoparticles / chemistry
  • Metal Nanoparticles / ultrastructure
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure*
  • Nanotechnology / methods*
  • Nucleic Acid Conformation


  • Gold
  • DNA