Neutrophil-to-Lymphocyte Ratio Positively Correlates to Age in Healthy Population

J Clin Lab Anal. 2015 Nov;29(6):437-43. doi: 10.1002/jcla.21791. Epub 2014 Oct 2.


Background: Neutrophil to lymphocyte ratio (NLR) was reported to be an independent easy-to-measure marker for many diseases, while the distribution of NLR in healthy population was not formally studied. So we investigated NLR in healthy people in this study.

Methods: Data include NLR, systolic pressure, diastolic pressure, and body mass index (BMI), which were collected from 3,262 healthy population. Correlations of NLR with variables were analyzed with SPSS16.0.

Results: Results demonstrated that NLR was positively associated with age (P < 0.001). The eldest age group possessed the highest NLR and the youngest age group had the lowest NLR. NLR was also slightly positively associated with systolic pressure, diastolic pressure, and BMI (P < 0.001).

Conclusion: Older people possessed relatively high NLR in healthy population.

Keywords: NLR; clinical parameter; immunity; lymphocyte; neutrophil.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Biomarkers / analysis*
  • Blood Pressure
  • Body Mass Index
  • Case-Control Studies
  • Disease / classification*
  • Female
  • Follow-Up Studies
  • Humans
  • Lymphocytes / pathology*
  • Male
  • Middle Aged
  • Neutrophils / pathology*
  • Prognosis
  • Young Adult


  • Biomarkers