Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Feb;92:18-22.
doi: 10.1016/j.phrs.2014.08.002. Epub 2014 Sep 30.

Predicting Post-Vaccination Autoimmunity: Who Might Be at Risk?

Affiliations
Review

Predicting Post-Vaccination Autoimmunity: Who Might Be at Risk?

Alessandra Soriano et al. Pharmacol Res. .

Abstract

Vaccinations have been used as an essential tool in the fight against infectious diseases, and succeeded in improving public health. However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced by adjuvants--ASIA syndrome). It has been postulated that autoimmunity could be triggered or enhanced by the vaccine immunogen contents, as well as by adjuvants, which are used to increase the immune reaction to the immunogen. Fortunately, vaccination-related ASIA is uncommon. Yet, by defining individuals at risk we may further limit the number of individuals developing post-vaccination ASIA. In this perspective we defined four groups of individuals who might be susceptible to develop vaccination-induced ASIA: patients with prior post-vaccination autoimmune phenomena, patients with a medical history of autoimmunity, patients with a history of allergic reactions, and individuals who are prone to develop autoimmunity (having a family history of autoimmune diseases; asymptomatic carriers of autoantibodies; carrying certain genetic profiles, etc.).

Keywords: Adjuvants; Allergy; Autoantibodies; Autoimmunity; Vaccine.

Similar articles

See all similar articles

Cited by 16 articles

See all "Cited by" articles

LinkOut - more resources

Feedback