Discovery and development of new antibacterial agents targeting Gram-negative bacteria in the era of pandrug resistance: is the future promising?

Curr Opin Pharmacol. 2014 Oct;18:91-7. doi: 10.1016/j.coph.2014.09.008. Epub 2014 Sep 29.


Multidrug-resistant Gram-negative bacteria continue to pose a threat, with many infections caused by these pathogens being virtually untreatable. A number of new antibacterial agents are in late stage clinical development to treat these infections. Drugs in known classes such as new quinolones, aminoglycosides, tetracyclines, and β-lactams have been designed to evade many of the known resistance mechanisms, whereas newer drug classes include novel β-lactamase inhibitors in combination with new or approved β-lactams, and a peptidomimetic that have entered full clinical development. The establishment of public-private partnerships and an increase in pharmaceutical interest in antibacterial R&D are encouraging signs for the future.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Drug Discovery
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Drugs, Investigational / pharmacology*
  • Gram-Negative Bacteria / drug effects*
  • Humans
  • Public-Private Sector Partnerships


  • Anti-Bacterial Agents
  • Drugs, Investigational