Metabolomics insights into pathophysiological mechanisms of interstitial cystitis

Int Neurourol J. 2014 Sep;18(3):106-14. doi: 10.5213/inj.2014.18.3.106. Epub 2014 Sep 24.


Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.

Keywords: Biological markers; Interstitial cystitis; Magnetic resonance spectroscopy; Mass spectrometry; Metabolomics.

Publication types

  • Review