Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis

Cancers (Basel). 2014 Oct 2;6(4):2049-71. doi: 10.3390/cancers6042049.


This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how it is regulated could lead to the development of novel therapeutic strategies.

Publication types

  • Review