Looking at LncRNAs with the ribozyme toolkit

Mol Cell. 2014 Oct 2;56(1):13-7. doi: 10.1016/j.molcel.2014.08.025.


A diverse population of large RNA molecules controls every aspect of cellular function, and yet we know very little about their molecular structures. However, robust technologies developed for visualizing ribozymes and riboswitches, together with new approaches for mapping RNA inside cells, provide the foundation for visualizing the structures of long noncoding RNAs, mRNAs, and viral RNAs, thereby facilitating new mechanistic insights.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gene Expression Regulation*
  • Models, Genetic*
  • Nucleic Acid Conformation
  • RNA Folding
  • RNA, Catalytic / chemistry
  • RNA, Catalytic / physiology*
  • RNA, Long Noncoding / chemistry
  • RNA, Long Noncoding / physiology*


  • RNA, Catalytic
  • RNA, Long Noncoding