Revisiting the flight of Icarus: making human organs from PSCs with large animal chimeras

Cell Stem Cell. 2014 Oct 2;15(4):406-409. doi: 10.1016/j.stem.2014.09.013.


While cell therapies hold great potential for treating many conditions, their utility for treating patients that require whole organ replacement is unclear. To address this challenge, we propose using genetically engineered "organ niches" in large animals to generate human organs from pluripotent stem cells and discuss the hurdles facing such strategies.

Publication types

  • Review

MeSH terms

  • Animals
  • Blastocyst / cytology
  • Chimera*
  • Humans
  • Organ Specificity*
  • Organogenesis*
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / transplantation
  • Stem Cell Transplantation / adverse effects
  • Stem Cell Transplantation / ethics