Novel PTM-TEMPO biradical for fast dissolution dynamic nuclear polarization

Org Lett. 2014 Oct 17;16(20):5402-5. doi: 10.1021/ol502644x. Epub 2014 Oct 3.


The synthesis and characterization of a novel trityl-TEMPO biradical and the investigation of its properties as Dynamic Nuclear Polarization (DNP) polarizing agent are reported. Comparison with a structurally related monoradical (PTM-TEMPE) or mixtures of the two monoradical components reveals that the biradical has a much higher polarization efficiency and a faster polarization buildup. This offers the possibility of faster recycling further contributing to its efficiency as a polarizing agent.

Publication types

  • Research Support, Non-U.S. Gov't