Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne

Acta Derm Venereol Suppl (Stockh). 1989;143:31-4. doi: 10.2340/000155551433134.

Abstract

In a series of investigations using 20% azelaic acid cream as a therapy for acne, it was found that the treatment, compared with its placebo, significantly reduced inflamed lesions after 1 month and non-inflamed lesions after 2 months. No changes in sebum excretion rate occurred, but a significant reduction, 15.9 to 10.5%, of free fatty acids of skin surface lipid was detected after 1 month. The follicular Micrococaceae density was significantly reduced after 1 month, and after 2 months there was a significant reduction in follicular Propionibacterium spp density. The final reductions were 2,500 and 44 fold, respectively.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / microbiology
  • Acne Vulgaris / physiopathology
  • Administration, Topical
  • Anti-Bacterial Agents
  • Clinical Trials as Topic
  • Dicarboxylic Acids / administration & dosage
  • Dicarboxylic Acids / therapeutic use*
  • Double-Blind Method
  • Fatty Acids, Nonesterified / metabolism
  • Female
  • Humans
  • Male
  • Micrococcaceae / drug effects
  • Propionibacterium / drug effects
  • Sebum / drug effects
  • Sebum / metabolism

Substances

  • Anti-Bacterial Agents
  • Dicarboxylic Acids
  • Fatty Acids, Nonesterified
  • azelaic acid