Long-term treatment of acne with 20% azelaic acid cream

Acta Derm Venereol Suppl (Stockh). 1989;143:40-4.


Preliminary clinical studies (2) proved the effectiveness of topical azelaic acid (AZA) in the treatment of acne vulgaris. During the period of 1982-86 we carried out two studies with 20% AZA cream in patients with acne to determine its clinical indications and therapeutic schedules. The first, open study was of 100 unselected patients of either sex, while a second group of 30 patients formed a part of a larger (309 patients) multicentre single-blind comparison of topical AZA vs. 5% benzoylperoxide (BPO) gel for the treatment of papulopustular acne. The rates of improvement obtained indicate that topical AZA can be considered an effective therapy chiefly for papulo-pustular acne, with a very good local tolerance.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / pathology
  • Administration, Topical
  • Adolescent
  • Adult
  • Benzoyl Peroxide / therapeutic use
  • Dicarboxylic Acids / administration & dosage
  • Dicarboxylic Acids / therapeutic use*
  • Female
  • Humans
  • Male
  • Multicenter Studies as Topic
  • Time Factors


  • Dicarboxylic Acids
  • azelaic acid
  • Benzoyl Peroxide