Intestinal colonization by a Lachnospiraceae bacterium contributes to the development of diabetes in obese mice

Microbes Environ. 2014;29(4):427-30. doi: 10.1264/jsme2.ME14054. Epub 2014 Oct 4.

Abstract

The aim of the present study was to identify bacteria that may contribute to the onset of metabolic dysfunctions. We isolated and identified a candidate bacterium belonging to Lachnospiraceae (strain AJ110941) in the feces of hyperglycemic obese mice. The colonization of germ-free ob/ob mice by AJ110941 induced significant increases in fasting blood glucose levels as well as liver and mesenteric adipose tissue weights, and decreases in plasma insulin levels and HOMA-β values. These results indicated that the specific gut commensal bacterium AJ110941 influenced the development of obesity and diabetes in ob/ob mice with genetic susceptibility for obesity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / analysis
  • Clostridiales / growth & development*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Diabetes Mellitus / microbiology*
  • Feces / microbiology
  • Gastrointestinal Tract / microbiology*
  • Gram-Positive Bacterial Infections / complications*
  • Insulin / blood
  • Liver / pathology
  • Mesentery / pathology
  • Mice, Obese
  • Molecular Sequence Data
  • Sequence Analysis, DNA

Substances

  • Blood Glucose
  • DNA, Bacterial
  • Insulin

Associated data

  • GENBANK/AB861470