Development of UK guidance on the management of erectile dysfunction resulting from radical radiotherapy and androgen deprivation therapy for prostate cancer

Int J Clin Pract. 2015 Jan;69(1):106-23. doi: 10.1111/ijcp.12512. Epub 2014 Oct 6.

Abstract

Aim: To develop a management strategy (rehabilitation programme) for erectile dysfunction (ED) after radiotherapy (RT) or androgen deprivation therapy (ADT) for prostate cancer that is suitable for use in a UK NHS healthcare context.

Methods: PubMed literature searches of ED management in this patient group together with a survey of 28 experts in the management of treatment-induced ED from across the UK were conducted.

Results: Data from 19 articles and completed questionnaires were collated. The findings discussed in this article confirm that RT/ADT for prostate cancer can significantly impair erectile function. While many men achieve erections through PDE5-I use, others need combined management incorporating exercise and lifestyle modifications, psychosexual counselling and other erectile aids. This article offers a comprehensive treatment algorithm to manage patients with ED associated with RT/ADT.

Conclusion: Based on published research literature and survey analysis, recommendations are proposed for the standardisation of management strategies employed for ED after RT/ADT. In addition to implementing the algorithm, understanding the rationale for the type and timing of ED management strategies is crucial for clinicians, men and their partners.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Androgen Antagonists / adverse effects*
  • Androgen Antagonists / therapeutic use
  • Antineoplastic Agents, Hormonal / adverse effects
  • Erectile Dysfunction / drug therapy
  • Erectile Dysfunction / therapy*
  • Humans
  • Male
  • Practice Guidelines as Topic*
  • Prostatic Neoplasms / drug therapy
  • Quality of Life
  • Radiotherapy / adverse effects*
  • United Kingdom

Substances

  • Androgen Antagonists
  • Antineoplastic Agents, Hormonal