Association between CLPTM1L-TERT rs401681 polymorphism and risk of pancreatic cancer: a meta-analysis

Clin Exp Med. 2015 Nov;15(4):477-82. doi: 10.1007/s10238-014-0316-3. Epub 2014 Oct 5.


Telomere biology plays a critical and complex role in the initiation and progression of cancer. Several recent studies have provided evidence that rs401681 polymorphisms in intronic region of cleft lip and palate trans-membrane 1-like (CLPTM1L) gene sequence are associated with pancreatic cancer (PC) development, but a comprehensive synopsis is not available. We performed a meta-analysis of 6 case-control studies that included 8,253 pancreatic cancer cases and 37,646 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95 % confidence intervals (CIs). Overall, this meta-analysis showed that rs401681 allele T was associated with a significantly increased PC risk (OR = 1.17, 95 % CI = 1.12-1.22, P heterpgeneity = 0.596 and I (2) = 0). Similarly, in the subgroup analysis by ethnicity, a significantly increased risk was found among Asians (OR = 1.15, 95 % CI = 1.07-1.24, P heterpgeneity = 0.297 and I (2) = 8.0 %) and among Caucasian (OR = 1.13, 95 % CI = 1.02-1.26, P heterpgeneity = 0.385 and I (2) = 0). No publication bias was found in the present study. This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese. Further large and well-designed studies are needed to confirm this association.

Keywords: Cleft lip and palate trans-membrane 1-like (CLPTM1L) gene; Pancreatic cancer; Polymorphism; Telomerase reverse transcriptase (TERT).

Publication types

  • Meta-Analysis

MeSH terms

  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Humans
  • Membrane Proteins / genetics*
  • Neoplasm Proteins / genetics*
  • Pancreatic Neoplasms / epidemiology*
  • Pancreatic Neoplasms / genetics*
  • Polymorphism, Single Nucleotide*
  • Risk Assessment
  • Telomerase / genetics*


  • CLPTM1L protein, human
  • Membrane Proteins
  • Neoplasm Proteins
  • TERT protein, human
  • Telomerase