Systemic side-effects of topical corticosteroids

Indian J Dermatol. 2014 Sep;59(5):460-4. doi: 10.4103/0019-5154.139874.


With the introduction of topical corticosteroids, a milestone has been achieved in dermatologic therapy; owing to its potent anti-inflammatory and ant proliferative effects, it became possible to treat some hitherto resistant dermatoses. But this magic drug can cause enough mischief if used inappropriately. Children are more susceptible to the systemic adverse effects because of enhanced percutaneous absorption through their tender skin. So, systemic side effects should be kept in mind while prescribing this therapeutically valuable topical medicament.

Keywords: Adverse effects; hypothalamus-pituitary-adrenal axis; infants and children; percutaneous absorption; topical corticosteroids.