Renal control of calcium, phosphate, and magnesium homeostasis
- PMID: 25287933
- PMCID: PMC4491294
- DOI: 10.2215/CJN.09750913
Renal control of calcium, phosphate, and magnesium homeostasis
Erratum in
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Correction. Renal control of calcium, phosphate, and magnesium homeostasis.Clin J Am Soc Nephrol. 2015 Oct 7;10(10):1886-7. doi: 10.2215/CJN.08840815. Epub 2015 Sep 17. Clin J Am Soc Nephrol. 2015. PMID: 26384363 Free PMC article. No abstract available.
Abstract
Calcium, phosphate, and magnesium are multivalent cations that are important for many biologic and cellular functions. The kidneys play a central role in the homeostasis of these ions. Gastrointestinal absorption is balanced by renal excretion. When body stores of these ions decline significantly, gastrointestinal absorption, bone resorption, and renal tubular reabsorption increase to normalize their levels. Renal regulation of these ions occurs through glomerular filtration and tubular reabsorption and/or secretion and is therefore an important determinant of plasma ion concentration. Under physiologic conditions, the whole body balance of calcium, phosphate, and magnesium is maintained by fine adjustments of urinary excretion to equal the net intake. This review discusses how calcium, phosphate, and magnesium are handled by the kidneys.
Keywords: calcium; cell and transport physiology; channel; electrolytes; ion; renal physiology.
Copyright © 2015 by the American Society of Nephrology.
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