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. 2014 Nov;24(11):615-6.
doi: 10.1016/j.tcb.2014.09.005. Epub 2014 Oct 3.

Brd4 Is on the Move During Inflammation

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Brd4 Is on the Move During Inflammation

Yali Xu et al. Trends Cell Biol. .
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Abstract

Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome. This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.

Keywords: BET bromodomain; Brd4; JQ1; NF-kB; enhancer; inflammation; p65; super-enhancer.

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