The regulation of antibody class expression

Immunol Today. 1987;8(4):122-6. doi: 10.1016/0167-5699(87)90865-6.


The regulation of antibody class expression has been an active and controversial area of research for many years. Although it is well established that T cells influence which antibody isotypes are produced during an immune response, their exact mode of action has not been delineated. In this review Judy Teale and Kristin Abraham briefly summarize current understanding of isotype regulation and describe the T cells and/or their factors which may provide the biological signals that induce the immunoglobulin class switch.