The interaction between the Fc portions of antibodies and Fc receptors (FcR) on monocytes and macrophages is well known for such immune effector functions as the phagocytosis of antibody-coated bacterial and viral particles. Two additional functions of this Fc-FcR interaction have been described recently and both relate to the regulatory aspects of immune responses. These interactions, discussed here by Tse Wen Chang, are involved in antigen presentation, T cell activation and proliferation, and antibody production.
Copyright © 1985. Published by Elsevier B.V.