[Metadoxine in alcohol-related pathology]

Clin Ter. 1989 Jul 31;130(2):115-22.
[Article in Italian]


Metadoxine is an active drug for treatment of acute and chronic alcohol intoxication, affecting both liver and brain function. The authors reviewed the international pharmacological and clinical literature on the drug which shows the potential usefulness of metadoxine in the treatment of alcohol-induced diseases. The case report concerns the results in 20 chronic alcoholics, admitted to the hospital for acute alcohol intake treated with metadoxine (one 500 mg tablet twice daily). Biohumoral hepatopathy parameters and clinical parameters of neuropsychic behaviour were examined simultaneously. Compared with a control group of patients undergoing traditional therapy (sedative and multi-vitamin drugs), metadoxine showed a significant improvement of the values of gamma-GT, GPT, blood ammonia, blood alcohol and of neuropsychic and behavioural parameters such as agitation, tremor, asterixis, sopor and depression. No side-effects or unfavourable reactions occurred during metadoxine treatment, which confirms the safety of this molecule.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Drug Combinations / therapeutic use
  • Female
  • Humans
  • Liver Diseases, Alcoholic / drug therapy*
  • Male
  • Middle Aged
  • Pyridoxine / therapeutic use*
  • Pyrrolidinones / therapeutic use*
  • Pyrrolidonecarboxylic Acid / therapeutic use*


  • Drug Combinations
  • Pyrrolidinones
  • metadoxine
  • Pyridoxine
  • Pyrrolidonecarboxylic Acid