Looking for the Roots of Cortical Sensory Computation in Three-Layered Cortices

Curr Opin Neurobiol. 2015 Apr;31:119-26. doi: 10.1016/j.conb.2014.09.006. Epub 2014 Oct 4.


Despite considerable effort over a century and the benefit of remarkable technical advances in the past few decades, we are still far from understanding mammalian cerebral neocortex. With its six layers, modular architecture, canonical circuits, innumerable cell types, and computational complexity, isocortex remains a challenging mystery. In this review, we argue that identifying the structural and functional similarities between mammalian piriform cortex and reptilian dorsal cortex could help reveal common organizational and computational principles and by extension, some of the most primordial computations carried out in cortical networks.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cerebral Cortex / cytology*
  • Computer Simulation*
  • Humans
  • Models, Neurological*
  • Nerve Net / physiology*
  • Sensory Receptor Cells / physiology*