Preliminary results on clinical effects of probiotic Lactobacillus salivarius LS01 in children affected by atopic dermatitis

J Clin Gastroenterol. Nov-Dec 2014;48 Suppl 1:S34-6. doi: 10.1097/MCG.0000000000000233.

Abstract

Goals: The goal of this study was to evaluate the clinical efficacy of an intake of Lactobacillus salivarius LS01 (DSM 22775) for the treatment of atopic dermatitis (AD) in children.

Background: AD is an inflammatory and pruritic chronic relapsing skin disorder with multifactorial etiopathology. Some evidence suggests that probiotics may improve AD by modulating the immune system and the composition of intestinal microbiota.

Study: A total of 43 patients aged from 0 to 11 years were enrolled in the study (M/F ratio=1:1) and treated with the probiotic strain L. salivarius LS01. Clinical efficacy of probiotic treatment was assessed from baseline by changes in itch index and in the objective SCORAD/SCORAD index.

Results: Patients being given probiotic treatment showed a significant improvement in clinical parameters (SCORAD and itch values) from baseline. The reduction in SCORAD and itch index observed after 4 weeks of treatment also persisted after the cessation of probiotic supplementation.

Conclusions: L. salivarius LS01 seems to be able to improve the quality of life of children affected by AD and, as a consequence, it may have promising clinical and research implications.

Publication types

  • Clinical Trial

MeSH terms

  • Child
  • Child, Preschool
  • Dermatitis, Atopic / diagnosis*
  • Dermatitis, Atopic / immunology
  • Dermatitis, Atopic / microbiology
  • Dermatitis, Atopic / therapy*
  • Female
  • Host-Pathogen Interactions
  • Humans
  • Infant
  • Infant, Newborn
  • Intestines / immunology
  • Intestines / microbiology*
  • Italy
  • Lactobacillus / classification
  • Lactobacillus / immunology
  • Lactobacillus / physiology*
  • Male
  • Probiotics / therapeutic use*
  • Pruritus / diagnosis
  • Pruritus / immunology
  • Pruritus / microbiology
  • Pruritus / therapy*
  • Quality of Life
  • Severity of Illness Index
  • Treatment Outcome