[Hypersexuality associated with aripiprazole: a new case and review of the literature]

Laura Vrignaud; Jerémie Aouille; Michel Mallaret; Geneviève Durrieu; Annie-Pierre Jonville-Béra

doi:10.2515/therapie/2014064

[Hypersexuality associated with aripiprazole: a new case and review of the literature]

Therapie. 2014 Nov-Dec;69(6):525-7. doi: 10.2515/therapie/2014064. Epub 2014 Oct 9.

[Article in French]

Authors

Laura Vrignaud¹, Jerémie Aouille², Michel Mallaret³, Geneviève Durrieu⁴, Annie-Pierre Jonville-Béra¹

Affiliations

¹ Centre régional de pharmacovigilance, de pharmacoépidémiologie et d'information sur le médicament, Service de pharmacologie clinique, CHRU de Tours, Tours, France.
² Cabinet de psychiatrie, Tours, France.
³ Centre régional de pharmacovigilance, CHU de Grenoble, Grenoble, France.
⁴ Service de pharmacologie médicale et clinique, Centre Midi-Pyrénées de pharmacovigilance, de pharmacoépidémiologie et d'informations sur le médicament, CHU de Toulouse et Faculté de médecine, Toulouse, France.

PMID: 25293487
DOI: 10.2515/therapie/2014064

Abstract

We report the case of a patient with hypersexuality while he was treated with aripiprazole since 6 months. Clinical manifestations were an increased libido, unusual frequent masturbation and sexual instincts. All have resolved upon discontinuation of aripiprazole, and recurred after it was restarted. The partial dopaminergic agonist effect of aripiprazole could probably explain the occurrence of this compulsive behaviour.

Publication types

Case Reports
English Abstract
Letter
Review

MeSH terms

Adult
Antipsychotic Agents / adverse effects*
Aripiprazole
Humans
Libido / drug effects*
Male
Obsessive-Compulsive Disorder / chemically induced
Obsessive-Compulsive Disorder / diagnosis
Piperazines / adverse effects*
Quinolones / adverse effects*
Schizophrenia / drug therapy
Sexual Dysfunction, Physiological / chemically induced*
Sexual Dysfunction, Physiological / diagnosis

Substances

Antipsychotic Agents
Piperazines
Quinolones
Aripiprazole