Apixaban exerts anti-inflammatory effects in mesangial cells by blocking thrombin/protease-activated receptor-1 system

Thromb Res. 2014 Dec;134(6):1365-7. doi: 10.1016/j.thromres.2014.09.028. Epub 2014 Sep 28.

Authors

Yuji Ishibashi¹, Takanori Matsui¹, Sho-ichi Yamagishi²

Affiliations

¹ Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan.
² Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan. Electronic address: shoichi@med.kurume-u.ac.jp.

PMID: 25294586
DOI: 10.1016/j.thromres.2014.09.028

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / pharmacokinetics*
Cells, Cultured
Dose-Response Relationship, Drug
Factor Xa Inhibitors / pharmacology
Humans
Mesangial Cells / drug effects*
Mesangial Cells / immunology*
Pyrazoles / pharmacology*
Pyridones / pharmacology*
Receptor, PAR-1 / immunology*
Thrombin / antagonists & inhibitors*
Thrombin / immunology*

Substances

Anti-Inflammatory Agents
Factor Xa Inhibitors
Pyrazoles
Pyridones
Receptor, PAR-1
apixaban
Thrombin