Caught in the act: multiple binding sites for memantine

Structure. 2014 Oct 7;22(10):1373-4. doi: 10.1016/j.str.2014.09.003.


In this issue of Structure, Ulens and colleagues demonstrate how an elegant combination of complementary functional and structural approaches can uncover both binding sites and conformational consequences associated with the Alzheimer's drug memantine binding to an ion channel.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Ligand-Gated Ion Channels / chemistry*
  • Ligand-Gated Ion Channels / metabolism*
  • Memantine / chemistry*


  • Ligand-Gated Ion Channels
  • Memantine