Wnt signaling in kidney tubulointerstitium during disease

Histol Histopathol. 2015 Feb;30(2):163-71. doi: 10.14670/HH-30.163. Epub 2014 Oct 9.


The evolutionary conserved Wnt signaling transduction pathway plays essential roles in a wide array of biologic processes including embryonic development, branching morphogenesis, proliferation and carcinogenesis. Over the past ten years it has become increasingly clear that Wnt signaling also regulates the response of adult organs to disease processes, including kidney disease. This review will focus on the growing literature implicating important roles for Wnt signaling during disease in two separate kidney compartments: the tubular epithelium and the interstitium.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Epithelium / physiopathology*
  • Female
  • Humans
  • Kidney / embryology*
  • Kidney / physiopathology*
  • Kidney Diseases / physiopathology*
  • Kidney Tubules / physiopathology*
  • Pregnancy
  • Signal Transduction
  • Wnt Proteins* / genetics


  • Wnt Proteins