Safety assessment of Vitis vinifera (grape)-derived ingredients as used in cosmetics

Int J Toxicol. 2014 Sep-Oct;33(3 Suppl):48S-83S. doi: 10.1177/1091581814545247.


The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 24 Vitis vinifera (grape)-derived ingredients and found them safe in the present practices of use and concentration in cosmetics. These ingredients function in cosmetics mostly as skin-conditioning agents, but some function as antioxidants, flavoring agents, and/or colorants. The Panel reviewed the available animal and clinical data to determine the safety of these ingredients. Additionally, some constituents of grapes have been assessed previously for safety as cosmetic ingredients by the Panel, and others are compounds that have been discussed in previous Panel safety assessments.

Keywords: Vitis vinifera; cosmetics; grape; safety.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinogenicity Tests
  • Consumer Product Safety*
  • Cosmetics / chemistry*
  • DNA Damage / drug effects
  • Female
  • Flowers / chemistry
  • Flowers / toxicity
  • Humans
  • Male
  • Plant Extracts / chemistry
  • Plant Extracts / toxicity*
  • Plant Leaves / chemistry
  • Plant Leaves / toxicity
  • Plant Roots / chemistry
  • Plant Roots / toxicity
  • Vitis / chemistry*


  • Cosmetics
  • Plant Extracts