A double-blind trial of treatment of seborrhoeic dermatitis with 2% ketoconazole cream compared with 1% hydrocortisone cream

Br J Dermatol. 1989 Sep;121(3):353-7. doi: 10.1111/j.1365-2133.1989.tb01429.x.

Abstract

Fifty patients with seborrhoeic dermatitis were treated with 2% ketoconazole cream (n = 24) or with 1% hydrocortisone cream (n = 26) for 4 weeks in a double-blind comparative study. These twice daily applications resulted in 87.2% symptomatic improvement for hydrocortisone vs. 81.6% for ketoconazole. The number of P. ovale yeasts was significantly reduced after the application of ketoconazole compared with hydrocortisone. The incidence of side-effects was low in both groups.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Anti-Inflammatory Agents / therapeutic use*
  • Dermatitis, Seborrheic / drug therapy*
  • Dermatitis, Seborrheic / microbiology
  • Double-Blind Method
  • Humans
  • Hydrocortisone
  • Ketoconazole / administration & dosage
  • Ketoconazole / therapeutic use*
  • Malassezia
  • Randomized Controlled Trials as Topic
  • Skin / microbiology

Substances

  • Anti-Inflammatory Agents
  • Ketoconazole
  • Hydrocortisone