Concealed dagger in FLT3/ITD+ AML

Blood. 2014 Oct 9;124(15):2317-9. doi: 10.1182/blood-2014-09-597690.

Abstract

In this issue of Blood, Ostronoff et al report a low remission rate in acute myeloid leukemia (AML) patients coexpressing FLT3/ITD and cryptic translocation t(5;11)(q35;p15.5), known as NUP98/NSD1.

Publication types

  • Comment

MeSH terms

  • Female
  • Humans
  • Leukemia, Myeloid, Acute / metabolism*
  • Leukemia, Myeloid, Acute / therapy*
  • Male
  • Oncogene Proteins, Fusion / metabolism*
  • fms-Like Tyrosine Kinase 3 / metabolism*

Substances

  • NUP98-NSD1 protein, human
  • Oncogene Proteins, Fusion
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3