Response to Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring"

Science. 2014 Oct 10;346(6206):176. doi: 10.1126/science.1256009.


Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of γ-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Autistic Disorder / chemically induced*
  • Autistic Disorder / genetics*
  • Cytoprotection*
  • Female
  • Oxytocin / metabolism*
  • Pregnancy
  • gamma-Aminobutyric Acid / metabolism*


  • Oxytocin
  • gamma-Aminobutyric Acid