[Treatment of acne vulgaris. A comparison of doxycycline versus minocycline]

Hautarzt. 1989 Sep;40(9):577-81.
[Article in German]


In the course of a randomized, comparative, clinical study, 50 patients with acne vulgaris received systemic treatment with a single daily dose of 50 mg doxycycline or two daily doses of 50 mg minocycline. At the completion of the 12-week treatment, cure or improvement of acne was found in 78% of the patients in the doxycycline group compared to 82% in the minocycline group. The rate of unsatisfactory therapeutic results was 22% in the doxycycline group and 18% in the group of patients treated with minocycline. The results showed no significant difference between the clinical efficacy of treating acne vulgaris with doxycycline at a daily dose of 50 mg and 100 mg of minocycline daily, a fact which has already been demonstrated by earlier studies.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Adolescent
  • Adult
  • Dose-Response Relationship, Drug
  • Doxycycline / administration & dosage*
  • Doxycycline / adverse effects
  • Female
  • Humans
  • Male
  • Minocycline / administration & dosage*
  • Minocycline / adverse effects
  • Randomized Controlled Trials as Topic
  • Tetracyclines / administration & dosage*


  • Tetracyclines
  • Minocycline
  • Doxycycline