Fascin1 in carcinomas: Its regulation and prognostic value

Int J Cancer. 2015 Dec 1;137(11):2534-44. doi: 10.1002/ijc.29260. Epub 2014 Oct 28.


Previous cell biological studies demonstrate that the actin bundling protein fascin1 regulates cell motility, migration and invasion. Human studies demonstrate that fascin1 is upregulated in many epithelial cancers. This review gives a brief overview of the role of fascin1 in cell migration and invasion, but focuses mainly on the regulation and clinical relevance of fascin1 in epithelial cancers. Here, we propose fascin1 as a potent prognostic biomarker for breast, colorectal, esophageal cancers and head and neck squamous cell carcinomas. Fascin1 may also be an attractive drug target against these carcinomas in the future, but more studies are needed.

Keywords: carcinomas; fascin1; prognostic marker.

Publication types

  • Review

MeSH terms

  • Animals
  • Carcinoma / metabolism*
  • Carcinoma / pathology*
  • Cell Movement / physiology
  • Humans
  • Microfilament Proteins / metabolism*
  • Neoplasm Invasiveness / pathology
  • Prognosis


  • Microfilament Proteins