Effects of intravascular low-level laser therapy during coronary intervention on selected growth factors levels

Photomed Laser Surg. 2014 Oct;32(10):582-7. doi: 10.1089/pho.2013.3700.

Abstract

Objective: The objective of this study was to evaluate the effect of intravascular low-level laser therapy (LLLT) on selected growth factor levels in subjects undergoing percutaneous coronary interventions (PCI).

Background data: Restenosis remains the main problem with the long-term efficacy of PCI, and growth factors are postulated to play a crucial role in the restenosis cascade.

Materials and methods: In a randomized prospective study, an 808 nm LLLT (100 mW/cm2, continuous wave laser, 9 J/cm2, illuminated area 1.6-2.5 cm2) was delivered intracoronarily to patients during PCI. Fifty-two patients underwent irradiation with laser light, and 49 constituted the control group. In all individuals, serum levels of insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1), and fibroblast growth factor-2 (FGF-2) were measured before angioplasty, then 6 and 12 h and 1 month after the procedure. In all patients, a control angiography was performed 6 months later.

Results: There were no significant differences in IGF-1 and VEGF levels between the groups. While evaluating FGF-2, we observed its significantly lower levels in the irradiated patients during each examination. There was a significant increase in TGF-β1 level in control group after 12 h of observation. In the irradiated individuals, control angiography revealed smaller late lumen loss and smaller late lumen loss index as compared with the control group. The restenosis rate was 15.0% in the treated group, and 32.4% in the control group, respectively.

Conclusions: LLLT decreases levels of TGF-β1 and FGF-2 in patients undergoing coronary intervention, which may explain smaller neointima formation.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Biomarkers / blood*
  • Coronary Angiography
  • Coronary Disease / therapy*
  • Female
  • Fibroblast Growth Factor 2 / blood
  • Humans
  • Insulin-Like Growth Factor I / metabolism
  • Low-Level Light Therapy*
  • Male
  • Middle Aged
  • Percutaneous Coronary Intervention / methods*
  • Prospective Studies
  • Transforming Growth Factor beta1 / blood
  • Treatment Outcome
  • Vascular Endothelial Growth Factor A / blood

Substances

  • Biomarkers
  • Transforming Growth Factor beta1
  • Vascular Endothelial Growth Factor A
  • Fibroblast Growth Factor 2
  • Insulin-Like Growth Factor I