Resveratrol and Endothelial Nitric Oxide

Molecules. 2014 Oct 9;19(10):16102-21. doi: 10.3390/molecules191016102.

Abstract

Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / drug therapy
  • Cardiovascular Diseases / metabolism
  • Endothelial Cells / drug effects*
  • Endothelial Cells / metabolism*
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / metabolism
  • Humans
  • Nitric Oxide / metabolism*
  • Nitric Oxide Synthase Type III / metabolism
  • Protein Binding
  • Resveratrol
  • Stilbenes / metabolism
  • Stilbenes / pharmacology*

Substances

  • Stilbenes
  • Nitric Oxide
  • Nitric Oxide Synthase Type III
  • Resveratrol