Is there a role for the MTHFR 677C>T and 1298A>C polymorphisms in methotrexate-induced liver toxicity?

Pharmacogenomics. 2014 Aug;15(11):1401-3. doi: 10.2217/pgs.14.82.

Authors

D Maroeska W M te Loo¹, Melanie M Hagleitner, Marieke J H Coenen

Affiliation

¹ Department of Pediatric Hematology & Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

PMID: 25303291
DOI: 10.2217/pgs.14.82

No abstract available

Keywords: MTX toxicity; meta-analysis; pharmacogenetics; pharmacogenomics; replication study.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Chemical and Drug Induced Liver Injury / genetics*
Humans
Liver / drug effects*
Methotrexate / adverse effects*
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Polymorphism, Genetic / genetics*

Substances

MTHFR protein, human
Methylenetetrahydrofolate Reductase (NADPH2)
Methotrexate