[Association Between interleukin-6 Polymorphism in the -174 G/C Region and Hearing Loss in the Elderly With a History of Occupational Noise Exposure]

Braz J Otorhinolaryngol. Sep-Oct 2014;80(5):373-8. doi: 10.1016/j.bjorl.2014.07.001. Epub 2014 Jul 22.
[Article in Portuguese]


Introduction: The biological processes involved in noise-induced hearing loss (NIHL) are still unclear. The involvement of inflammation in this condition has been suggested.

Objective: To investigate the association between interleukin - 6 (IL-6) polymorphism and susceptibility to NIHL.

Methods: This was a cross-sectional study with a sample of 191 independent elderly individuals aged >60 years of age. Information on exposure to occupational noise was obtained by interviews. Audiological evaluation was performed using pure tone audiometry and genotyped through PCR by restriction fragment length polymorphism - PCR-RFLP. Data were analyzed using the chi-square test and the odds ratio (OR), with the significance level set at 5%.

Results: Among elderly with hearing loss (78.0%), 18.8% had a history of exposure to occupational noise. There was a statistically significant association between the genotype frequencies of the IL-6 -174 and NIHL. The elderly with the CC genotype were less likely to have hearing loss due to occupational noise exposure when compared to those carrying the GG genotype (OR=0.0124; 95% CI 0.0023-0.0671; p<0.001).

Conclusion: This study suggests there is an association of polymorphisms in the IL-6 gene at position - G174C with susceptibility to noise-induced hearing loss.

Keywords: Citocinas; Cytokines; Occupational noise; Perda auditiva neurossensorial; Ruído ocupacional; Sensorineural hearing loss.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Audiometry, Pure-Tone
  • Cross-Sectional Studies
  • Female
  • Gene Frequency
  • Gene-Environment Interaction
  • Genetic Predisposition to Disease
  • Genotype
  • Hearing Loss, Noise-Induced / genetics*
  • Humans
  • Interleukin-6 / genetics*
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics*
  • Polymorphism, Restriction Fragment Length


  • Interleukin-6