Movement of microtubules by single kinesin molecules

Nature. 1989 Nov 9;342(6246):154-8. doi: 10.1038/342154a0.


Kinesin is a motor protein that uses energy derived from ATP hydrolysis to move organelles along microtubules. Using a new technique for measuring the movement produced in vitro by individual kinesin molecules, it is shown that a single kinesin molecule can move a microtubule for several micrometers. New information about the mechanism of force generation by kinesin is presented.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Triphosphatases / physiology*
  • Adenosine Triphosphate / metabolism
  • Animals
  • Cattle
  • Cell Movement
  • Cell-Free System
  • In Vitro Techniques
  • Kinesins
  • Microtubule Proteins / physiology*
  • Microtubules / physiology*
  • Video Recording


  • Microtubule Proteins
  • Adenosine Triphosphate
  • Adenosine Triphosphatases
  • Kinesins